Research Topics
A prerequisite to most of our research topics is glycan profiling in diseases for disease-specific glycan maker discovery. This is done through glycomics, specifically the glycoblotting technique- a high throughput technique utilizing hydrazide-functionalized polymer beads for easy chemoselective ligation and capture of glycans onto the polymer beads. This glycan capturing strategy allows facile on-bead derivatization and subsequent release of labeled glycans for MS or MS/MS analyses.
Compared to other glycomic techniques, glycoblotting requires only a minute amount of sample (~50 ug protein) for analysis, which is advantageous in analyzing limited amount of biological samples such as those that are acquired through core needle biopsy or cell culture.
The following are the priority projects of this laboratory.
Compared to other glycomic techniques, glycoblotting requires only a minute amount of sample (~50 ug protein) for analysis, which is advantageous in analyzing limited amount of biological samples such as those that are acquired through core needle biopsy or cell culture.
The following are the priority projects of this laboratory.